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Am J Pathol. 2013 Jul;183(1):3-9. doi: 10.1016/j.ajpath.2013.03.001.

New roles of cyclin D1.

Author information

1
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. director@kimmelcancercenter.org

Abstract

Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensing and DNA damage repair, and feedback governing expression of the noncoding genome. This review describes the mechanisms of these new functions of cyclin D1.

PMID:
23790801
PMCID:
PMC3702737
DOI:
10.1016/j.ajpath.2013.03.001
[Indexed for MEDLINE]
Free PMC Article
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