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Trends Neurosci. 2013 Sep;36(9):504-12. doi: 10.1016/j.tins.2013.05.003. Epub 2013 Jun 19.

Neuronal circuits that regulate feeding behavior and metabolism.

Author information

1
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

Abstract

Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals.

KEYWORDS:

GABA; agouti-related peptide; electrophysiology; glutamate; melanocortin receptor; neuropeptide Y receptor

PMID:
23790727
PMCID:
PMC3769497
DOI:
10.1016/j.tins.2013.05.003
[Indexed for MEDLINE]
Free PMC Article

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