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Chem Biol. 2013 Jun 20;20(6):745-6. doi: 10.1016/j.chembiol.2013.06.001.

Ins and outs of kinase DFG motifs.

Author information

1
KINOMEscan Division of DiscoveRx Corporation, 11180 Roselle Street, Suite D, San Diego, CA, 92121, USA. dtreiber@discoverx.com

Abstract

In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.

PMID:
23790484
DOI:
10.1016/j.chembiol.2013.06.001
[Indexed for MEDLINE]
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