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Asian Pac J Trop Med. 2013 Aug;6(8):595-601. doi: 10.1016/S1995-7645(13)60103-0.

In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus.

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1
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Abstract

OBJECTIVE:

To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis.

METHODS:

The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis (M. philippinensis) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus (E. granulosus), under in-vitro conditions with reference to the known standard drug Praziquantel®.

RESULTS:

At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation.

CONCLUSIONS:

As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

PMID:
23790329
DOI:
10.1016/S1995-7645(13)60103-0
[Indexed for MEDLINE]
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