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Pediatr Blood Cancer. 2013 Nov;60(11):E140-2. doi: 10.1002/pbc.24622. Epub 2013 Jun 20.

Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature.

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Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.


No standard treatment has been established in childhood blastic plasmacytoid dendritic cell neoplasma (BPDCN) because of its rarity. We treated with acute lymphoblastic leukemia-type regimen for a child with BPDCN with skin and leukemic involvement. She has been disease-free for 4 years after allogeneic bone marrow transplantation in first complete remission. In 33 cases of pediatric BPDCN, the over survival was significantly lower in the patients with skin manifestation than those without cutaneous involvement. Accordingly, it is important to determine whether allogeneic hematopoietic stem cell transplantation should be applied to first complete remission in the patients with poor prognosis.


blastic plasmacytoid dendritic cell neoplasm; bone marrow transplantation; childhood; skin involvement

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