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J Formos Med Assoc. 2013 Jun;112(6):302-11. doi: 10.1016/j.jfma.2013.02.001. Epub 2013 Mar 17.

Hepatitis B viral factors and treatment responses in chronic hepatitis B.

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Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan.


Baseline and on-treatment hepatitis B viral factors are reported to affect treatment responses. A lower baseline hepatitis B virus (HBV) DNA level is a strong predictor of the response to antiviral therapy. HBV genotype A/B patients have better responses to interferon-based therapy than those with genotypes C/D. Regarding the association of HBV mutants with responses to antiviral therapy, current evidence is limited. On-treatment viral suppression is the most important predictor of response to nucleoside analogs. On-treatment hepatitis B surface antigen decline is significantly associated with response to pegylated interferon. In the future, individualized therapy should be based on treatment efficacy, adverse effects, baseline and on-treatment predictors of antiviral therapy.

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