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FEBS J. 2013 Oct;280(20):5015-29. doi: 10.1111/febs.12399. Epub 2013 Jul 12.

Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity.

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Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada.


Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.


diet resistance; mitochondria; obesity; oxidative phosphorylation; proton leak; uncoupling; weight loss

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