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J Appl Res Intellect Disabil. 2014 May;27(3):247-63. doi: 10.1111/jar.12062. Epub 2013 Jun 19.

Vision deficits in adults with Down syndrome.

Author information

1
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

Abstract

BACKGROUND:

In individuals with Down syndrome, virtually all structures of the eye have some abnormality, which likely diminishes vision. We examined basic vision functions in adults with Down syndrome.

MATERIALS AND METHODS:

Participants completed a battery of psychophysical tests that probed a comprehensive array of visual functions. The performance of adults with Down syndrome was compared with younger and older adults without intellectual disability.

RESULTS:

Adults with Down syndrome had significant vision deficits, reduced sensitivity across spatial frequencies and temporal modulation rates, reduced stereopsis, impaired vernier acuity and anomalies in colour discrimination. The pattern of deficits observed was similar to those seen by researchers examining adults with Alzheimer's disease.

CONCLUSIONS:

Our findings suggest that a common mechanism may be responsible for the pattern of deficits observed, possibly the presence of Alzheimer's disease neuropathology in the visual association cortex. We also showed that individuals with mild to moderate intellectual disability are capable of participating in studies employing state-of-the-art psychophysical procedures. This has wider implications in terms of their ability to participate in research that use similar techniques.

KEYWORDS:

Alzheimer's disease; Down syndrome; ageing; intellectual disability; vision; vision deficits

PMID:
23784802
PMCID:
PMC3841243
DOI:
10.1111/jar.12062
[Indexed for MEDLINE]
Free PMC Article
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