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Liver Int. 2013 Sep;33(8):1194-202. doi: 10.1111/liv.12224. Epub 2013 Jun 19.

Association between the hepatitis B and C viruses and metabolic diseases in patients stratified by age.

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Department of Occupation Medicine, Keelung Chang-Gung Memorial Hospital, Keelung, Taiwan.



Hepatitis B/C viruses cause liver disease and metabolic disturbances.


The purpose of this study was to evaluate the association between hepatitis B/C infection and metabolic syndrome (MS).


In total, 26,305 subjects were included in this multicentre, cross-sectional study. Systolic and diastolic blood pressures, body mass index and waist circumference were measured. Total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, fasting blood glucose and uric acid were determined, and hepatitis B serum antigen (HBsAg) and anti-HCV antibodies were assayed using commercial kits.


MS was diagnosed in 2712 (23.0%) females, including 131 and 166 positive for HBsAg and anti-HCV respectively. In the men, 4594 (31.6%) were diagnosed with MS, including 326 positive for HBsAg and 131 positive for anti-HCV. No significant difference in the prevalence of MS was identified in any group, except men and women >45 years who were anti-HCV positive. Various metabolic alterations in both men and women >45 years were noted, including waist circumference, body mass index, fasting blood glucose and systolic and diastolic blood pressure. Notably, high- and low-density lipoproteins were significantly lower in positive subjects compared to those weakly positive and/or negative for anti-HCV.


There were obvious metabolic derangements in patients coinflicted with MS and hepatitis C infections, particularly those >45 years of age. There is a pressing need to identify strategies to improve/resolve metabolic derangements to maximize sustained virological response rates in patients infected with HCV (and potentially HBV).


hepatitis B; hepatitis C; insulin resistance; lipid metabolism; metabolic syndrome

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