Format

Send to

Choose Destination
J Peripher Nerv Syst. 2013 Jun;18(2):162-7. doi: 10.1111/jns5.12027.

Evaluation of dermal myelinated nerve fibers in diabetes mellitus.

Author information

1
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. amanda.peltier@vanderbilt.edu

Abstract

Skin biopsies have primarily been used to study the non-myelinated nerve fibers of the epidermis in a variety of neuropathies. In this study, we have expanded the skin biopsy technique to glabrous, non-hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (DPN). Twenty patients with DPN (Type I, n = 9; Type II, n = 11) and 16 age-matched healthy controls (age 29-73) underwent skin biopsy of the index finger, nerve conduction studies (NCS), and composite neuropathy scoring. In patients with DPN, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (MCs) and their afferent myelinated nerve fibers (p = 0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in NCS. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with DPN.

PMID:
23781963
PMCID:
PMC3693761
DOI:
10.1111/jns5.12027
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center