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Pharm Methods. 2012 Jul;3(2):98-101. doi: 10.4103/2229-4708.103885.

Development and validation of spectrophotometric method for simultaneous estimation of paracetamol and lornoxicam in different dissolution media.

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1
Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Near ArvindBaug, Mehsana, Gujarat, India.

Abstract

BACKGROUND:

Paracetamol and lornoxicam in combined tablet dosage form are available in the market. This combination is used to treat inflammatory diseases of the joints, osteoarthritis and sciatica. Spectrophotometric and high performance liquid chromatography (HPLC) methods have been reported for their simultaneous estimation in tablet dosage form in specific solvent. This paper presents simple, accurate and reproducible spectrophotometric method for simultaneous determination of paracetamol and lornoxicam in tablet dosage form in different dissolution media. The reported method is helpful in determination of paracetamol and lornoxicam during dissolution study.

MATERIALS AND METHODS:

Simple, sensitive, accurate and economical spectrophotometric method based on an absorption correction equation was developed for the estimation of paracetamol and lornoxicam simultaneously in tablet dosage form in different dissolution media at different pH.

RESULTS:

Paracetamol showed absorption maxima at 243 nm in 0.1N HCland phosphate buffer pH 6.8, while lornoxicam showed absorption maxima at 374 nm in 0.1N HCland phosphate buffer pH 6.8. The linearity was obtained in the concentration range of 4-12 μg/ml for paracetamol and 4-16 μg/ ml for lornoxicam.

DISCUSSION:

The concentrations of the drugs were determined by an absorption correction equation method. The results of analysis have been validated statistically by recovery studies.

KEYWORDS:

Absorption correction method; dissolution media; lornoxicam; paracetamol

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