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Evid Based Complement Alternat Med. 2013;2013:280418. doi: 10.1155/2013/280418. Epub 2013 May 28.

Primo vascular system in the subarachnoid space of a mouse brain.

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Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon 443-270, Republic of Korea ; Department of Research & Development, Peace World Medical Co., Ltd., Seoul 110-775, Republic of Korea ; Nadi Primo Research Institute, Graduate School of Integrative Medicine, Sun Moon University, Asan-si 336-708, Republic of Korea.



Recently, a novel circulatory system, the primo vascular system (PVS), was found in the brain ventricles and in the central canal of the spinal cord of a rat. The aim of the current work is to detect the PVS along the transverse sinuses between the cerebrum and the cerebellum of a mouse brain.


The PVS in the subarachnoid space was analyzed after staining with 4',6-diamidino-2-phenylindole (DAPI) and phalloidin in order to identify the PVS. With confocal microscopy and polarization microscopy, the primo vessel underneath the sagittal sinus was examined. The primo nodes under the transversal sinuses were observed after peeling off the dura and pia maters of the brain.


The primo vessel underneath the superior sagittal sinus was observed and showed linear optical polarization, similarly to the rabbit and the rat cases. The primo nodes were observed under the left and the right transverse sinuses at distances of 3,763  μ m and 5,967  μ m. The average size was 155  μ m × 248  μ m.


The observation of primo vessels was consistent with previous observations in rabbits and rats, and primo nodes under the transverse sinuses were observed for the first time in this work.

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