Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Discov. 2013 Oct;3(10):1130-41. doi: 10.1158/2159-8290.CD-13-0135. Epub 2013 Jun 18.

Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death.

Author information

1
1Department of Pathology; 2James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine; 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health; 4Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; Departments of 5Nutrition and 6Epidemiology, Harvard School of Public Health; and 7Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 8Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

Abstract

Current prognostic indicators are imperfect predictors of outcome in men with clinically localized prostate cancer. Thus, tissue-based markers are urgently needed to improve treatment and surveillance decision-making. Given that shortened telomeres enhance chromosomal instability and such instability is a hallmark of metastatic lesions, we hypothesized that alterations in telomere length in the primary cancer would predict risk of progression to metastasis and prostate cancer death. To test this hypothesis, we conducted a prospective cohort study of 596 surgically treated men who participated in the ongoing Health Professionals Follow-up Study. Men who had the combination of more variable telomere length among prostate cancer cells (cell-to-cell) and shorter telomere length in prostate cancer-associated stromal (CAS) cells were substantially more likely to progress to metastasis or die of their prostate cancer. These findings point to the translational potential of this telomere biomarker for prognostication and risk stratification for individualized therapeutic and surveillance strategies.

SIGNIFICANCE:

In this prospective study, the combination of more variable telomere length among cancer cells and shorter telomere length in CAS cells was strongly associated with progression to metastasis and prostate cancer death, pointing to the translational potential for prognostication and risk stratifi cation for individualized therapeutic and surveillance strategies.

PMID:
23779129
PMCID:
PMC3797255
DOI:
10.1158/2159-8290.CD-13-0135
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center