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Nat Rev Mol Cell Biol. 2013 Jul;14(7):452-9. doi: 10.1038/nrm3602. Epub 2013 Jun 19.

A self-organization framework for symmetry breaking in the mammalian embryo.

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1
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. Recent experimental advances have revealed unexpected dynamics of and new complexity in this process. These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system.

PMID:
23778971
DOI:
10.1038/nrm3602
[Indexed for MEDLINE]

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