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Nat Immunol. 2013 Jul;14(7):654-9. doi: 10.1038/ni.2614.

Resident viruses and their interactions with the immune system.

Author information

1
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Abstract

The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.

PMID:
23778792
PMCID:
PMC3760236
DOI:
10.1038/ni.2614
[Indexed for MEDLINE]
Free PMC Article

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