Format

Send to

Choose Destination
Br J Cancer. 2013 Jul 23;109(2):493-6. doi: 10.1038/bjc.2013.299. Epub 2013 Jun 18.

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.

Author information

1
Department of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands. a.koopmans@erasmusmc.nl

Abstract

BACKGROUND:

Mutations in GNAQ and GNA11, encoding the oncogenic G-protein alpha subunit q and 11, respectively, occur frequently in the majority of uveal melanomas.

METHODS:

Exons 4 and 5 from GNAQ and GNA11 were amplified and sequenced from 92 ciliary body and choroidal melanomas. The mutation status was correlated with disease-free survival (DFS) and other parameters.

RESULTS:

None of the tumours harboured a GNAQ exon 4 mutation. A GNAQ mutation in exon 5 codon 209 was found in 46 out of 92 (50.0%) of the tumours. Only 1 out of 92 (1.1%) melanomas showed a mutation in GNA11 exon 4 codon 183, whereas 39 out of 92 (42.4%) harboured a mutation in exon 5 of GNA11 codon 209. Six tumours did not show any mutations in exons 4 and 5 of these genes. Univariate analyses showed no correlation between DFS and the mutation status.

CONCLUSION:

GNAQ and GNA11 mutations are, in equal matter, not associated with patient outcome.

PMID:
23778528
PMCID:
PMC3721402
DOI:
10.1038/bjc.2013.299
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center