Format

Send to

Choose Destination
Ophthalmology. 2013 Dec;120(12):2396-2402. doi: 10.1016/j.ophtha.2013.05.010. Epub 2013 Jun 15.

One-year outcomes from a prospective, randomized, eye-to-eye comparison of wavefront-guided and wavefront-optimized LASIK in myopes.

Author information

1
Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
2
Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California. Electronic address: edward.manche@stanford.edu.

Abstract

OBJECTIVE:

To compare wavefront (WF)-guided and WF-optimized LASIK in myopes.

DESIGN:

Prospective, randomized, eye-to-eye study.

PARTICIPANTS:

A total of 72 eyes of 36 participants with myopia with or without astigmatism.

METHODS:

Participants were randomized to receive WF-guided or WF-optimized LASIK with the WaveLight Allegretto Eye-Q 400-Hz excimer laser platform (Alcon, Inc., Hüenberg, Switzerland). LASIK flaps were created using the 150-kHz IntraLase iFS (Abbott Medical Optics, Santa Ana, CA). Evaluations included measurement of uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), <5% and <25% contrast sensitivity, and WF aberrometry. Patients also completed a validated questionnaire detailing symptoms on a quantitative scale.

MAIN OUTCOME MEASURES:

Safety, efficacy, predictability, refractive error, UDVA, CDVA, contrast sensitivity, and higher-order aberrations (HOAs).

RESULTS:

The frequency with which the WF-guided and WF-optimized groups achieved postoperative UDVA of ≥ 20/16 or ≥ 20/20 and the frequency with which the groups lost 1 or 2 or more lines or maintained their preoperative CDVA were not statistically different from each other (all P > 0.05). The frequency with which the WF-guided group attained a refractive error within ± 0.25 diopters of emmetropia was higher than in the WF-optimized group (67.6%, 95% confidence interval [CI], 50.4-84.8 vs. 41.2%, 95% CI, 23.2-59.2; P = 0.03). The WF-guided group's mean UDVA was better than the WF-optimized group's UDVA by approximately 1 Early Treatment Diabetic Retinopathy Study line (-0.17 ± 0.11 logarithm of the minimum angle of resolution [logMAR], slightly <20/12 Snellen vs. -0.13 ± 0.12, slightly >20/16; P = 0.05). There were no statistically significant differences in contrast sensitivity, astigmatism, coma, or higher-order root mean square error between the groups (all P > 0.05), but the WF-guided group had less trefoil compared with the WF-optimized group (0.14 ± 0.07 vs. 0.20 ± 0.09; P < 0.01). There were no statistically significant differences in subjective parameters between the groups (all P > 0.05).

CONCLUSIONS:

Wavefront-guided and WF-optimized LASIK using the Alcon WaveLight Allegretto Eye-Q 400-Hz excimer laser platform provide similar results in myopic patients; however, the WF-guided approach may yield small gains in visual acuity, predictability, and HOAs.

PMID:
23778091
DOI:
10.1016/j.ophtha.2013.05.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center