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Clin Exp Dermatol. 2013 Jul;38(5):478-83. doi: 10.1111/ced.12171.

Leptin levels in patients with psoriasis: a meta-analysis.

Author information

1
Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China. zhukunju1111@163.com

Abstract

BACKGROUND:

There have been inconsistent results reported for leptin levels in patients with psoriasis.

AIM:

To evaluate leptin levels in patients with psoriasis using a meta-analysis of studies comparing leptin levels in controls and in patients with psoriasis.

METHODS:

PubMed (MEDLINE), EMBASE and the Cochrane Library were searched for relevant papers published in English. Pooled weighted mean differences (WMDs) and 95% CIs were calculated using random-effects and fixed-effects models. Heterogeneity between studies was assessed using the Cochran Q and I(2) statistics.

RESULTS:

In total, 11 studies, comprising 773 patients with psoriasis and 570 healthy controls, were identified. Leptin levels were significantly higher in patients with psoriasis compared with controls (WMD = 7.24, 95% CI 4.55-9.93; P < 0.001). On stratified analysis, significant differences in leptin levels between patients with psoriasis and controls were reported only in serum samples (P < 0.001), and not in plasma samples (P = 0.025). Sensitivity analysis showed that there were no changes in the direction of effect when any one study was excluded. No publication bias was detected.

CONCLUSIONS:

Leptin levels are higher in patients with psoriasis compared with those in controls. Future studies are warranted to clarify the association between leptin levels and the pathomechanism of psoriasis.

PMID:
23777488
DOI:
10.1111/ced.12171
[Indexed for MEDLINE]
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