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Indian J Endocrinol Metab. 2013 Jan;17(1):44-9. doi: 10.4103/2230-8210.107834.

Luteal insufficiency in first trimester.

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Gynaecworld and Gynaecworld Assisted Fertility Unit Mumbai, Gynaecworld, Mumbai, India.


Luteal phase insufficiency is one of the reasons for implantation failure and has been responsible for miscarriages and unsuccessful assisted reproduction. Luteal phase defect is seen in women with polycystic ovaries, thyroid and prolactin disorder. Low progesterone environment is created iatrogenically due to interventions in assisted reproduction. Use of gonadotrophin-releasing hormone analogs to prevent the LH surge and aspiration of granulosa cells during the oocyte retrieval may impair the ability of corpus luteum to produce progesterone. Treatment of the underlying disorder and use of progestational agents like progesterone/human chorionic gonadotrophin have been found to be effective in women with a history of recurrent miscarriage. There has been no proved beneficial effect of using additional agents like ascorbic acid, estrogen, prednisolone along with progesterone. Despite their widespread use, further studies are required to establish the optimal treatment. Literature review and analysis of published studies on luteal phase support.


Assisted reproduction; human chorionic gonadotrophin; luteal phase support; miscarriage; progesterone

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