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Indian J Occup Environ Med. 2012 Sep;16(3):145-8. doi: 10.4103/0019-5278.111765.

Papillon-Lefevre syndrome-like presentation in chronic arsenicosis: A rare mimicry.

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Department of Medicine, College of Medicine and JNM Hospital, Kalyani, Nadia, India.


Chronic arsenicosis is a major health and occupational problem in rural parts of West Bengal such as in parts of the Gangetic plain of India. Chronic arsenicosis occurs due to accidental ingestion of repeated amounts of small doses by those working with metal or by taking food or drink in which there are traces of arsenic. Chronic exposure may result accumulation in the hair, nail, and skin. Arsenic can also cross the placenta. Papillon-Lefèvre syndrome is a rare disease characterized by skin lesions caused by palmar-plantar hyperkeratosis and severe periodontal destruction involving both the primary and permanent dentitions. Until date, more than 200 cases have been reported worldwide. Palmoplantar hyperkeratosis is a major manifestation in both chronic arsenicosis and Papillon-Lefèvre syndrome. We report herein a rare case of chronic arsenicosis in a patient from rural Bengal, whose all features mimic Papillon-Lefèvre syndrome. It is probably the first case of Papillon-Lefevre syndrome-like presentation in chronic arsenicosis from India.


Chronic arsenicosis; Papillon-Lefevre syndrome; palmar-plantar hyperkeratosis

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