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Methods Mol Biol. 2013;1034:41-70. doi: 10.1007/978-1-62703-493-7_2.

Antibodies in transplantation: the effects of HLA and non-HLA antibody binding and mechanisms of injury.

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1
Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Abstract

Until recently, allograft rejection was thought to be mediated primarily by alloreactive T cells. Consequently, immunosuppressive approaches focused on inhibition of T cell activation. While short-term graft survival has significantly improved and rejection rates have dropped, acute rejection has not been eliminated and chronic rejection remains the major threat to long-term graft survival. Increased attention to humoral immunity in experimental systems and in the clinic has revealed that donor specific antibodies (DSA) can mediate and promote acute and chronic rejection. Herein, we detail the effects of alloantibody, particularly HLA antibody, binding to graft vascular and other cells, and briefly summarize the experimental methods used to assess such outcomes.

PMID:
23775730
PMCID:
PMC3879955
DOI:
10.1007/978-1-62703-493-7_2
[Indexed for MEDLINE]
Free PMC Article
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