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Brain Struct Funct. 2014 Sep;219(5):1697-707. doi: 10.1007/s00429-013-0595-6. Epub 2013 Jun 18.

Cognitive subtypes of dyslexia are characterized by distinct patterns of grey matter volume.

Author information

1
Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Pasteur 3, 02-093, Warsaw, Poland, k.jednorog@nencki.gov.pl.

Abstract

The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research was directly devoted to the investigation of structural brain correlates of these subtypes. Here, for the first time, we applied voxel-based morphometry (VBM) to study grey matter volume (GMV) differences in a relatively large sample (n = 46) of dyslexic children split into three subtypes based on the cognitive deficits: phonological, rapid naming, magnocellular/dorsal, and auditory attention shifting. VBM revealed GMV clusters specific for each studied group including areas of left inferior frontal gyrus, cerebellum, right putamen, and bilateral parietal cortex. In addition, using discriminant analysis on these clusters 79% of cross-validated cases were correctly re-classified into four groups (controls vs. three subtypes). Current results indicate that dyslexia may result from distinct cognitive impairments characterized by distinguishable anatomical markers.

PMID:
23775490
PMCID:
PMC4147248
DOI:
10.1007/s00429-013-0595-6
[Indexed for MEDLINE]
Free PMC Article

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