Format

Send to

Choose Destination
Semin Reprod Med. 2013 Jul;31(4):293-300. doi: 10.1055/s-0033-1345277. Epub 2013 Jun 17.

Nutrient supplementation: improving male fertility fourfold.

Author information

1
Division of Urology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA.

Abstract

Oxidative stress can contribute to impairment in spermatogenesis leading to male-factor infertility. The effectiveness of various antioxidants (such as carnitine, vitamin C, vitamin E, selenium, carotenoids, glutathione, N-acetylcysteine, zinc, folic acid, and coenzyme Q10) is variable with respect to improving semen parameters and pregnancy rates. A recent Cochrane review determined that men taking antioxidants had a statistically significant increase in both live birth rates and pregnancy rates. For those undergoing assisted reproduction, the odds ratio that antioxidant use would improve pregnancy rates was 4.18, with a 4.85-fold improvement in live birth rate also noted. Further investigation with randomized, controlled clinical trials is needed to confirm the safety and efficacy of antioxidant supplementation in the medical management and treatment of male infertility.

PMID:
23775385
DOI:
10.1055/s-0033-1345277
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Georg Thieme Verlag Stuttgart, New York
Loading ...
Support Center