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Laryngoscope. 2014 Jan;124(1):188-195. doi: 10.1002/lary.24254. Epub 2013 Jul 9.

Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy.

Author information

1
Harvard Medical School, Boston, MA.
2
Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary / Harvard Medical School, Boston, MA.
3
Department of Pathology, Massachusetts General Hospital, Boston, MA.
4
Division of Otolaryngology, Beth Israel Medical Center, Boston, MA; Department of Pathology, Beth Israel Medical Center, Boston, MA.
#
Contributed equally

Abstract

OBJECTIVES/HYPOTHESIS:

To review the known histopathologic findings and clinical behavior of mammary analogue secretory carcinoma (MASC).

DATA SOURCES:

PubMed.

REVIEW METHODS:

Literature search using the terms "Mammary analogue secretory carcinoma," "Mammary analog secretory carcinoma," and "MASC" to identify all relevant publications.

RESULTS:

MASC is an unusual and rare malignant salivary gland tumor first described in 2010. It shares histologic, immunohistochemical, and genetic features with secretory carcinoma of the breast. The clinical behavior of MASC ranges from slowly growing tumors that infrequently recur after surgical resection to aggressive tumors that cause widespread metastasis and death. Many cases of MASC were discovered in archived cases previously classified as acinic cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma not otherwise specified.

CONCLUSION:

MASC is a newly recognized variant of salivary gland malignancy. Further research is needed to better delineate its overall prevalence and to define an appropriate treatment algorithm for this new clinical entity.

KEYWORDS:

Salivary gland carcinoma; head and neck surgery; mammary analogue secretory carcinoma; parotid malignancy

PMID:
23775296
PMCID:
PMC4500055
DOI:
10.1002/lary.24254
[Indexed for MEDLINE]
Free PMC Article
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