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J Mol Med (Berl). 2013 Aug;91(8):907-16. doi: 10.1007/s00109-013-1060-y. Epub 2013 Jun 18.

Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling.

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1
Department of Pharmacology, University of California, Davis, Genome Building, Rm 3503, Davis, CA 95616-8636, USA. jbossuyt@ucdavis.edu

Abstract

Calcium (Ca(2+)) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca(2+)-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca(2+)-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca(2+)-CaM and Ca(2+)-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

PMID:
23775230
PMCID:
PMC3962229
DOI:
10.1007/s00109-013-1060-y
[Indexed for MEDLINE]
Free PMC Article
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