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Nat Rev Genet. 2013 Jul;14(7):507-15. doi: 10.1038/nrg3457.

Pitfalls of predicting complex traits from SNPs.

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1
Queensland Brain Institute, The University of Queensland, QBI Building, St Lucia, Queensland 4071, Australia.

Abstract

The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.

PMID:
23774735
PMCID:
PMC4096801
DOI:
10.1038/nrg3457
[Indexed for MEDLINE]
Free PMC Article

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