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Neuropsychobiology. 2013;68(1):59-62. doi: 10.1159/000350998. Epub 2013 Jun 15.

No association between a polymorphism in the serotonin receptor 2B (HTR2B) gene and personality traits in healthy Japanese subjects.

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Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.



The brain neurotransmitter serotonin affects many aspects of human behavior, including personality traits. Because the serotonin receptor 2B (HTR2B) gene has recently been associated with impulsivity, we investigated the potential association between the rs10194776 and Q20* polymorphism in the HTR2B gene and personality traits in healthy subjects.


A total of 1,171 healthy Japanese subjects were enrolled in this study. Their personality traits were evaluated using the Temperament and Character Inventory (TCI), and the rs10194776 and Q20* genotype was determined using real-time polymerase chain reaction.


There was a significant main effect of the rs10194776 polymorphism on harm avoidance and self-directedness in females (p = 0.037 and p = 0.043, respectively). However, these differences were insignificant after a Bonferroni correction. Subjects carrying the minor allele of the Q20* polymorphism were nonexistent.


The results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity.

[Indexed for MEDLINE]

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