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Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct;114:114-9. doi: 10.1016/j.saa.2013.04.122. Epub 2013 May 15.

Targeting triple negative breast cancer cells by N3-substituted 9,10-phenanthrenequinone thiosemicarbazones and their metal complexes.

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  • 1Department of Life & Physical Sciences, Lincoln University, Jefferson City, MO 65101, USA. afrasiabiz@lincolnu.edu

Abstract

Novel N(3)-substituted 9,10-Phenanthrenequinone thiosemicarbazones and their copper, nickel and palladium complexes are structurally characterized and reported along with the single crystal X-ray structures of three ligands and one nickel complex. All compounds were evaluated for their antiproliferative potential against Triple Negative Breast Cancer (TNBC) cells which have poor prognosis and no effective drugs to treat with. All compounds exhibited antiproliferative activity against these cells. Among the metal complexes evaluated, redox active copper complexes were found to be more potent. The possible mechanism for such enhanced activity can be attributed to the generation of oxidative stress, which was amenable for targeting through metal complexation.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

9,10-Phenanthrenequinone; Antiproliferative activity; Copper complex; N(3)-substituted thiosemicarbazones; Triple negative breast cancer

[PubMed - indexed for MEDLINE]
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