Format

Send to

Choose Destination
See comment in PubMed Commons below
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Sep;116(3):327-35. doi: 10.1016/j.oooo.2013.04.011. Epub 2013 Jun 14.

Highly aggressive human papillomavirus-related oropharyngeal cancer: clinical, radiologic, and pathologic characteristics.

Author information

1
Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, OH 43212, USA. Azeem.kaka@osumc.edu

Abstract

OBJECTIVE:

Although the majority of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas have a favorable prognosis, we search for markers of poor prognosis by carefully examining a subset of highly aggressive cases.

STUDY DESIGN:

Seven patients with HPV-positive oropharyngeal cancer who presented with non-pulmonary distant metastasis or developed distant metastasis posttreatment were identified. Eight control cases were chosen which responded well to treatment. Pathologic and radiologic studies were reviewed and compared.

RESULTS:

Two cases displayed a small cell carcinoma (SmCC) component upon pathologic review. Biomarker analysis revealed lower expression of NOTCH1 in the aggressive cohort in comparison to controls (P = .04). Cases showed a predominance of clustering of lymph nodes, extracapsular spread, and central tumor necrosis.

CONCLUSION:

Although most HPV-related oropharyngeal cancers display a positive prognosis, it is evident that there is a subset, which behaves more aggressively. This early investigation identifies pathologic and radiologic features that may help to predict this behavior.

PMID:
23770280
PMCID:
PMC3748144
DOI:
10.1016/j.oooo.2013.04.011
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center