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Cell Stem Cell. 2013 Aug 1;13(2):237-45. doi: 10.1016/j.stem.2013.05.006. Epub 2013 Jun 13.

Tet1 regulates adult hippocampal neurogenesis and cognition.

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1
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet1 exhibit impaired hippocampal neurogenesis accompanied by poor learning and memory. In adult neural progenitor cells deficient in Tet1, a cohort of genes involved in progenitor proliferation were hypermethylated and downregulated. Our results indicate that Tet1 is positively involved in the epigenetic regulation of neural progenitor cell proliferation in the adult brain.

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PMID:
23770080
PMCID:
PMC4474382
DOI:
10.1016/j.stem.2013.05.006
[Indexed for MEDLINE]
Free PMC Article

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