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Mol Oncol. 2013 Aug;7(4):743-55. doi: 10.1016/j.molonc.2013.04.008. Epub 2013 May 15.

Translating next generation sequencing to practice: opportunities and necessary steps.

Author information

1
Philips Research North America, Briarcliff Manor, NY 10510, USA. sitharthk@philips.com

Abstract

Next-generation sequencing (NGS) approaches for measuring RNA and DNA benefit from greatly increased sensitivity, dynamic range and detection of novel transcripts. These technologies are rapidly becoming the standard for molecular assays and represent huge potential value to the practice of oncology. However, many challenges exist in the transition of these technologies from research application to clinical practice. This review discusses the value of NGS in detecting mutations, copy number changes and RNA quantification and their applications in oncology, the challenges for adoption and the relevant steps that are needed for translating this potential to routine practice.

KEYWORDS:

Genomics; Next generation sequencing; Oncology; Personalized medicine

PMID:
23769412
DOI:
10.1016/j.molonc.2013.04.008
[Indexed for MEDLINE]
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