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Eur Urol. 2013 Nov;64(5):734-41. doi: 10.1016/j.eururo.2013.05.050. Epub 2013 Jun 6.

Oncologic, functional, and complications outcomes of robot-assisted radical cystectomy with totally intracorporeal neobladder diversion.

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1
Department of Molecular Medicine and Surgery, Section of Urology, Karolinska Institutet, Stockholm, Sweden.

Abstract

BACKGROUND:

Robot-assisted radical cystectomy (RARC) with totally intracorporeal neobladder diversion is a complex procedure that has been reported with good outcomes in small series.

OBJECTIVE:

To present complications and oncologic and functional outcomes of this procedure.

DESIGN, SETTING, AND PARTICIPANTS:

Between 2003 and 2012 in a tertiary referral center, 70 patients were operated on by two experienced robotic surgeons. Data were collected prospectively and reviewed retrospectively.

INTERVENTION:

RARC with totally intracorporeal modified Studer ileal neobladder formation.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:

The overall outcome of RARC with a totally intracorporeal neobladder was presented by assessing (1) surgical margins, (2) recurrence or cancer-specific death at 24 mo, (3) 30-d and 90-d complications graded according to the modified Clavien-Dindo system, (4) daytime and nighttime continence (no or one pad per day) at 6 and 12 mo, and (5) satisfactory sexual activity or potency at 6 mo and 12 mo. Survival rates were estimated by Kaplan-Meier plots.

RESULTS AND LIMITATIONS:

Median follow-up of the cohort was 30.3 mo (interquartile range: 12.7-35.6). We recorded negative margins in 69 of 70 patients (98.6%). Clavien 3-5 complications occurred in 22 of 70 patients (31.4%) at 30 d and 13 of 70 (18.6%) at >30 d. At 90 d, the overall complication rate was 58.5%. Clavien <3 and Clavien ≥3 complications were recorded in 15 of 70 patients (21.4%) and 26 of 70 (37.1%), respectively. Kaplan-Meier estimates for recurrence-free, cancer-specific, and overall survival at 24 mo were 80.7%, 88.9%, and 88.9%, respectively. Daytime continence and satisfactory sexual function or potency at 12 mo ranged between 70% and 90% in both men and women. Limitations of this study include its retrospective design, selection bias due to the learning curve phase, and missing data.

CONCLUSIONS:

In this expert center for RARC, outcomes after RARC with totally intracorporeal neobladder diversion appear satisfactory and in line with contemporary open series.

KEYWORDS:

Complications; Continence; Ileal neobladder; Intracorporeal; Potency; Radical cystectomy; Recurrence; Robot assisted; Sexual function; Studer pouch; Surgical margins

PMID:
23768634
DOI:
10.1016/j.eururo.2013.05.050
[Indexed for MEDLINE]

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