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J Am Podiatr Med Assoc. 1990 Aug;80(8):414-8.

Vitamin C influence on localized adjuvant arthritis.

Author information

1
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

Abstract

This work attempts to determine the influence of vitamin C on locally induced inflammation and arthritis in rat paws, as measured by rat paw swelling, polymorphonuclear leukocyte infiltration, pain, and surface skin temperature. Daily subcutaneous administration of 150 mg/kg of vitamin C over 20 days reduced arthritic swelling, increased pain tolerance, and decreased polymorphonuclear leukocyte infiltration, with no significant change in surface temperature. Vitamin C may provide podiatrists with a supplemental or alternative treatment for patients with rheumatoid arthritis.

PMID:
2376830
DOI:
10.7547/87507315-80-8-414
[Indexed for MEDLINE]

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