Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7684-9. doi: 10.1002/anie.201302881. Epub 2013 Jun 13.

Abstract

Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).

Keywords: antigen; mucosal immunity; mucus delivery; nanomicelles; nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Animals
  • Antigens, Viral / immunology
  • Drug Carriers / administration & dosage*
  • Drug Carriers / pharmacokinetics
  • Drug Delivery Systems*
  • Immunity, Humoral / immunology
  • Immunity, Mucosal / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Mucus / drug effects
  • Mucus / immunology
  • Nanoparticles / administration & dosage*
  • Ovalbumin / administration & dosage
  • Ovalbumin / immunology
  • Polyglutamic Acid / analogs & derivatives
  • Polyglutamic Acid / chemistry
  • Polymers / administration & dosage*
  • Polymers / pharmacokinetics
  • Tissue Distribution
  • Vaccination
  • Vaccines / administration & dosage*
  • Vaccines / immunology*

Substances

  • Antigens, Viral
  • Drug Carriers
  • Polymers
  • Vaccines
  • poly(gamma-glutamic acid)
  • Polyglutamic Acid
  • Ovalbumin