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Am J Clin Pathol. 2013 Jul;140(1):55-60. doi: 10.1309/AJCPHBL59MWBVYRD.

Academic and nonacademic laboratories perform equally on CIQC immunohistochemistry proficiency testing.

Author information

1
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

Abstract

OBJECTIVES:

To test whether academic centers (ACs) are more successful than nonacademic centers (NACs) in immunohistochemistry (IHC) external quality assessment challenges in the Canadian Immunohistochemistry Quality Control (CIQC) program.

METHODS:

Results of 9 CIQC challenges for breast cancer marker (BM) and various non-breast cancer marker (NBM) tests were examined. Success rates were compared between AC/NAC laboratories and those located in small or large cities. Performance was also correlated with annual IHC case volumes.

RESULTS:

There was no statistically significant difference in performance in any of the comparisons. However, overall performance on BM was significantly better (P < .0001, t test) than on NBM tests regardless of AC/NAC nature or city size. The mean failure rate on NBM was approximately twice that of BM tests.

CONCLUSION:

Our results suggest that recent emphasis on breast hormone IHC quality assurance has led to improved test quality.

KEYWORDS:

Academic center; External quality assessment; Immunohistochemistry; Proficiency testing

PMID:
23765534
DOI:
10.1309/AJCPHBL59MWBVYRD
[Indexed for MEDLINE]

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