Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Mol Sci. 2013 Jun 13;14(6):12484-95. doi: 10.3390/ijms140612484.

Facile synthesis of 5-arylidene thiohydantoin by sequential sulfonylation/desulfination reaction.

Author information

  • 1Department of Applied Chemistry, China Agricultural University, Beijing 100193, China. wangma@cau.edu.cn.

Abstract

The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent yields. A plausible sulfonylation/desulfination mechanism was proposed. The bioassay showed that these compounds exhibit certain fungicidal activities with the 71.9% inhibition rate of 2K against B. cinerea, and 57.6% inhibition rate of 2m against A. solani, respectively.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Write to the Help Desk