Send to

Choose Destination
See comment in PubMed Commons below
Int J Mol Sci. 2013 Jun 13;14(6):12484-95. doi: 10.3390/ijms140612484.

Facile synthesis of 5-arylidene thiohydantoin by sequential sulfonylation/desulfination reaction.

Author information

  • 1Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.


The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent yields. A plausible sulfonylation/desulfination mechanism was proposed. The bioassay showed that these compounds exhibit certain fungicidal activities with the 71.9% inhibition rate of 2K against B. cinerea, and 57.6% inhibition rate of 2m against A. solani, respectively.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Write to the Help Desk