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Bioresour Technol. 2013 Aug;142:523-9. doi: 10.1016/j.biortech.2013.05.004. Epub 2013 May 10.

Ectoine production from lignocellulosic biomass-derived sugars by engineered Halomonas elongata.

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Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1, Rokkodai-Cho, Nada, Kobe 657-8501, Japan.


In this study, the water-retaining cyclic amino acid ectoine was produced from a variety of sugars, including glucose, xylose, cellobiose, and glucose/xylose mixture using engineered Halomonas elongata. When grown on xylose as the sole carbon source, H. elongata produced 333 mmol/kg fresh cell weight (FW) of ectoine, which was 1.4-fold higher than that produced from glucose. To improve ectoine production, an ectD deficient H. elongata mutant was constructed. The engineered H. elongata produced 377 mmol/kg FW of ectoine from a glucose/xylose mixture. Ectoine was also produced from rice straw hydrolysate. These results show that H. elongata can produce ectoine from a variety of sugars derived from lignocellulosic biomass and thus has tremendous potential as a host for producing useful compounds from biomass resources.


Ectoine; Halomonas elongata; Lignocellulosic biomass; Rice straw hydrolysate; Xylose

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