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Org Biomol Chem. 2013 Aug 21;11(31):5065-8. doi: 10.1039/c3ob40915e. Epub 2013 Jun 13.

Quick and reversible photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside in a DNA triplex.

Author information

1
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa 923-1292, Japan. kenzo@jaist.ac.jp

Abstract

3-Cyanovinylcarbazole nucleoside ((CNV)K), which can quickly photocrosslink to the pyrimidine base in the DNA double strand, was incorporated into a triplex forming oligonucleotide (TFO). We successfully demonstrated that (CNV)K in TFO can photocrosslink to the thymine base in Watson-Crick double-stranded DNA via anti-Hoogsteen base pairing with a few seconds of photoirradiation.

PMID:
23764762
DOI:
10.1039/c3ob40915e
[Indexed for MEDLINE]

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