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Emerg Infect Dis. 2013 Jul;19(7):1138-41. doi: 10.3201/1907.130313.

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

Author information

1
Imperial College London, London, UK. s.hingley-wilson@surrey.ac.uk

Abstract

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

KEYWORDS:

Mycobacterium tuberculosis; TB; antimicrobial resistance; bacteria; co-infection; drug sensitive; multidrug resistant; treatment resistance; tuberculosis and other mycobacteria

PMID:
23764343
PMCID:
PMC3713993
DOI:
10.3201/1907.130313
[Indexed for MEDLINE]
Free PMC Article

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