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Prog Mol Biol Transl Sci. 2013;118:3-18. doi: 10.1016/B978-0-12-394440-5.00001-2.

Arrestins come of age: a personal historical perspective.

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  • 1Department of Medicine, Duke University Medical Center, and Howard Hughes Medical Institute, Durham, NC, USA.

Abstract

Visual arrestin and the two β-arrestins (1 and 2) were originally discovered 25-30 years ago in the context of their ability to desensitize phosphorylated G protein-coupled receptors (rhodopsin and the β2-adrenergic receptor, respectively). A fourth retinal-specific member of the family (X-arrestin) was discovered later. Over the past 10-15 years, however, it has become clear that these versatile molecules subserve a host of other roles in modulating and mediating the function of most GPCRs as well as other types of receptors. Functioning as multifunctional adaptor proteins, the β-arrestins also play prominent roles in receptor endocytosis, signaling, trafficking, and ubiquitination among others. Here, I provide a brief personal perspective on how the field has evolved since its inception and speculate on future directions.

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