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Oncoimmunology. 2013 May 1;2(5):e24212.

Attenuated measles virus used as an oncolytic virus activates myeloid and plasmacytoid dendritic cells.

Author information

1
INSERM; UMR892; Nantes, France ; CNRS; UMR6299; Nantes, France ; Université de Nantes; Nantes, France.

Abstract

Attenuated measles viruses (MV) are assessed in clinical trials for their capacity to preferentially infect and kill tumor cells. We recently showed that MV-infected tumor cells are able to activate tumor antigen cross-presentation by myeloid and plasmacytoid dendritic cells. Thus, MV-based antitumor virotherapy may stimulate antitumor immune response.

KEYWORDS:

cytotoxic CD8+ T cell; measles virus vaccine; myeloid DC; oncolytic virus; plasmacytoid DC; tumor antigen

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