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Oncoimmunology. 2013 May 1;2(5):e24170.

Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.

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1
Medizinische Klinik und Poliklinik IV; Klinikum der Universität München; Munich, Germany.

Abstract

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5'-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced immunosuppression. This strategy showed therapeutic efficacy in a murine model of pancreatic cancer.

KEYWORDS:

RIG-I; TGFβ; immunosuppression; pancreatic cancer; siRNA

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