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Oncoimmunology. 2013 May 1;2(5):e23852. Epub 2013 Apr 15.

The two faces of regulatory T cells in cancer.

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Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Chicago, IL USA.


Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.


RORγt; Treg; colon-cancer; inflammation; polyposis

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