Format

Send to

Choose Destination
See comment in PubMed Commons below
J Physiol Sci. 2013 Sep;63(5):355-67. doi: 10.1007/s12576-013-0271-x. Epub 2013 Jun 13.

Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study.

Author information

1
Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa 252-0882, Japan.

Abstract

Early embryonic rodent ventricular cells exhibit spontaneous action potential (AP), which disappears in later developmental stages. Here, we used 3 mathematical models-the Kyoto, Ten Tusscher-Panfilov, and Luo-Rudy models-to present an overview of the functional landscape of developmental changes in embryonic ventricular cells. We switched the relative current densities of 9 ionic components in the Kyoto model, and 160 of 512 representative combinations were predicted to result in regular spontaneous APs, in which the quantitative changes in Na(+) current (I Na) and funny current (I f) made large contributions to a wide range of basic cycle lengths. In all three models, the increase in inward rectifier current (I K1) before the disappearance of I f was predicted to result in abnormally high intracellular Ca(2+) concentrations. Thus, we demonstrated that the developmental changes in APs were well represented, as I Na increased before the disappearance of I f, followed by a 10-fold increase in I K1.

PMID:
23760774
PMCID:
PMC3751412
DOI:
10.1007/s12576-013-0271-x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center