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J Invest Dermatol. 2013 Jul;133(7):1719-21. doi: 10.1038/jid.2013.137.

Systemic protein therapy for recessive dystrophic epidermolysis bullosa: how far are we from clinical translation?

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1
University Paris Descartes Sorbonne Paris Cité, Imagine Institute, Paris, France. alain.hovnanian@inserm.fr

Abstract

In this issue, Woodley et al. report restoration of anchoring fibril formation and dermal-epidermal adherence in a murine model of recessive dystrophic epidermolysis bullosa (RDEB) by intravenous injection of recombinant human type VII collagen. This work follows a previous report by the same group of the surprising capability of intradermally injected type VII collagen protein to reverse RDEB, and it opens new therapeutic avenues.

PMID:
23760051
DOI:
10.1038/jid.2013.137
[Indexed for MEDLINE]
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