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Vet Immunol Immunopathol. 2014 Mar 15;158(1-2):98-104. doi: 10.1016/j.vetimm.2013.05.006. Epub 2013 May 10.

Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells.

Author information

1
School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China. Electronic address: chunxiasu@yahoo.com.cn.
2
Laboratory Examination College, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China; Laboratory Examination Research Institute, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China; Stem Cell Research Institute, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
3
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
4
School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
5
Pharmacy College, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
6
Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, Ningxia, 640100, PR China.

Abstract

Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immune-modulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In our current study, we found that LBP were able to activate CXCR5+PD-1+ Tfh cells and induce IL-21 secretion. At the same time LBP also promoted the formation of germinal centers (GC) and production of GL-7+B220+GC B cells. LBP as an adjuvant could increase generation of rAd5VP1-induced Tfh cells. Our results indicate that LBP might enhance T cell-dependent Ab responses by acting as an adjuvant for the generation of Tfh cells. Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects.

KEYWORDS:

Adjuvant; Follicular helper T cells; Lycium barbarum polysaccharides

PMID:
23759470
DOI:
10.1016/j.vetimm.2013.05.006
[Indexed for MEDLINE]
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