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BMC Genomics. 2013 Jun 7;14:381. doi: 10.1186/1471-2164-14-381.

Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis.

Author information

1
Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA.

Abstract

BACKGROUND:

The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated that loss of Fra-1 leads to exacerbated bleomycin-induced pulmonary fibrosis, accompanied by enhanced expression of various inflammatory and fibrotic genes. To better understand the molecular mechanisms by which Fra-1 confers protection during bleomycin-induced lung injury, genome-wide mRNA expression profiling was performed.

RESULTS:

We found that Fra-1 regulates gene expression programs that include: 1) several cytokines and chemokines involved in inflammation, 2) several genes involved in the extracellular remodeling and cell adhesion, and 3) several genes involved in programmed cell death.

CONCLUSION:

Loss of Fra-1 leads to the enhanced expression of genes regulating inflammation and immune responses and decreased the expression of genes involved in apoptosis, suggesting that this transcription factor distinctly modulates early pro-fibrotic cellular responses.

PMID:
23758685
PMCID:
PMC3685523
DOI:
10.1186/1471-2164-14-381
[Indexed for MEDLINE]
Free PMC Article

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