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J Antibiot (Tokyo). 2014 Jan;67(1):7-22. doi: 10.1038/ja.2013.49. Epub 2013 Jun 12.

Prospects for new antibiotics: a molecule-centered perspective.

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Biological Chemistry and Molecular Pharmacology Department, Harvard Medical School, Boston, MA, USA.


There is a continuous need for iterative cycles of antibiotic discovery and development to deal with the selection of resistant pathogens that emerge as therapeutic application of an antibiotic becomes widespread. A short golden age of antibiotic discovery from nature followed by a subsequent golden half century of medicinal chemistry optimization of existing molecular scaffolds emphasizes the need for new antibiotic molecular frameworks. We bring a molecule-centered perspective to the questions of where will new scaffolds come from, when will chemogenetic approaches yield useful new antibiotics and what existing bacterial targets merit contemporary re-examination.

[Indexed for MEDLINE]

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