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Bone. 2013 Sep;56(1):213-9. doi: 10.1016/j.bone.2013.05.022. Epub 2013 Jun 10.

Vertebral fractures and abdominal aortic calcification in postmenopausal women. A cohort study.

Author information

1
Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco. aelmaghraoui@gmail.com

Abstract

INTRODUCTION:

Vertebral fracture assessment (VFA) imaging with a bone densitometer can simultaneously detect prevalent vertebral fractures (VFs) and abdominal aortic calcification (AAC).

OBJECTIVE:

To study the relation between the prevalence of VFs using VFA in asymptomatic women and the prevalence and severity of AAC.

DESIGN:

This is a cross-sectional study.

SETTINGS:

Subjects were recruited in a third care center from asymptomatic women selected from the general population.

PARTICIPANTS:

We enrolled 908 post-menopausal women with a mean age of 60.9 years ± 7.7 (50 to 91) with no prior known diagnosis of osteoporosis or taking medication interfering with bone metabolism.

PRIMARY AND SECONDARY OUTCOME MEASURES:

Lateral VFA images and scans of the lumbar spine and proximal femur were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative (SQ) approach and morphometry. VFA images were scored for AAC using a validated 24 point scale.

RESULTS:

VFA images showed that 179 of the participants (19.7%) had at least one grade 2/3 VF, 81% did not have any detectable AAC whereas the prevalence of significant atherosclerotic burden, defined as AAC score of 5 or higher, was 12%. The group of women with 2/3 VFs had a statistically significant higher AAC score and higher proportion of subjects with extended AAC, and lower weight, height, and lumbar spine and hip BMD and T-scores than those without VFA-identified VFs. Multiple regression analysis showed that the presence of grade 2/3 VFs was significantly associated with age, BMI, history of peripheral fracture, AAC score ≥ 5 and densitometric osteoporosis.

CONCLUSION:

In post-menopausal women, extended AAC is independently associated with prevalent VFs regardless of age, BMI, history of fractures, and BMD.

KEYWORDS:

Abdominal aortic calcification; Dual-energy X-ray absorptiometry (DXA); Osteoporosis; Vertebral fracture assessment (VFA); Vertebral fractures; Women

PMID:
23756234
DOI:
10.1016/j.bone.2013.05.022
[Indexed for MEDLINE]
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