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Pharmacol Ther. 2013 Oct;140(1):81-91. doi: 10.1016/j.pharmthera.2013.06.001. Epub 2013 Jun 10.

Regulation of metabolism by cGMP.

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Institute of Pharmacology and Toxicology, Biomedical Center, University of Bonn, Germany. Electronic address:


The second messenger cyclic guanosine monophosphate (cGMP) mediates the physiological effects of nitric oxide and natriuretic peptides in a broad spectrum of tissues and cells. So far, the major focus of research on cGMP lay on the cardiovascular system. Recent evidence suggests that cGMP also plays a major role in the regulation of cellular and whole-body metabolism. Here, we focus on the role of cGMP in adipose tissue. In addition, other organs important for the regulation of metabolism and their regulation by cGMP are discussed. Targeting the cGMP signaling pathway could be an exciting approach for the regulation of energy expenditure and the treatment of obesity.


Brown adipose tissue; Browning; Metabolism; Obesity; White adipose tissue; cGMP

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